At the OER Foundation, we have the convention of using Docker to deploy most components of the web services we offer. One notable exception to that is the way we deploy our most widely used database. Rather than deploying a separate MySQL/MariaDB container for every service on a given host, we instead deploy a single instance running on the host. We do this for a couple reasons:
I have previously provided an in-depth explanation about NextCloud with Collabora Office Online and how we've installed it on Ubuntu 16.04. This is an update both of the process, and of the technology.
Update 2021-11-08: this post is now getting a bit long-in-the-tooth, and I need to update it to use up-to-date components. It might still be useful to folks, but use it with caution. Also, please note, we're using NextCloud with OnlyOffice (the open source community edition) these days.